The 2018 IEEE International Symposium on Power Line Communications and its Applications (ISPLC) will be the 22nd symposium dedicated to scientific and technical advances in the field of communications over power lines. The event is sponsored by IEEE Communications Society (IEEE ComSoc). The conference will be held in Manchester, United Kingdom, from April 8th to April 11th , 2018. IEEE ISPLC 2018 main topic is “PLC for Smart Grid and Beyond”” and will focus on industry applications of power line communications, theoretical and practical aspects of communications theory, algorithms, channel and noise measurements, EMC, simulation and real implementations, evaluation and lessons from field trials and related experience, network planning, installation, operation and management, protocols, cybersecurity, standards and regulations pertaining to communications via power lines. One of the main features of ISPLC is strong industry participation; it brings together researchers, practitioners and users of PLC technology. The conference will further include a series of keynote and experts’ panel talks, as well as an Industry Exhibit centred on PLC for Smart Grids. Acceptance of submissions will be based on quality, relevance, and originality, with awards for the best submissions. Accepted papers will be published in the IEEE ISPLC 2018 Conference Proceedings and in IEEE Xplore®.